Analysis of Ovarian Cancer Genes

Grant number: 566603 | Funding period: 2009 - 2011

Completed

Abstract

In Australia in 2001 there were ~1300 new cases of ovarian cancer. Survival of ovarian cancer is very poor and current treatments inadequate. To develop more effective treatments we need to understand the molecular events that cause ovarian cancer. Some genes have multiple copies in ovarian cancer cells and these may be good targets for therapy. We aim to find these genes and determine which ones have a functional effect in the tumour.

Related publications (4)

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Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

JMB Pang, P Savas, AP Fellowes, G Mir Arnau, T Kader, R Vedururu, C Hewitt, EA Takano, DJ Byrne, DYH Choong, EKA Millar, C Soon Lee, SA O'Toole, SR Lakhani, MC Cummings, G Bruce Mann, IG Campbell, A Dobrovic, S Loi, KL Gorringe

2017-07-01

The spectrum of genomic alterations in ductal carcinoma in situ (DCIS) is relatively unexplored, but is likely to provide useful i..

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Enhanced GAB2 expression is associated with improved survival in high-grade serous ovarian cancer and sensitivity to PI3K inhibition

SJ Davis, KE Sheppard, MS Anglesio, J George, N Traficante, S Fereday, MP Intermaggio, U Menon, A Gentry-Maharaj, J Lubinski, J Gronwald, CL Pearce, MC Pike, A Wu, S Kommoss, J Pfisterer, AD Bois, F Hilpert, SJ Ramus, DDL Bowtell

2015-06-01

Identification of genomic alterations defining ovarian carcinoma subtypes may aid the stratification of patients to receive target..

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Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer

SJ Davis, KE Sheppard, RB Pearson, IG Campbell, KL Gorringe, KJ Simpson

2013-03-15

Purpose: Ovarian cancer has the highest mortality rate of all the gynecologic malignancies and is responsible for approximately 14..

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Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis

M Ramakrishna, LH Williams, SE Boyle, JL Bearfoot, A Sridhar, TP Speed, KL Gorringe, IG Campbell

2010-09-10

Ovarian cancer is a disease characterised by complex genomic rearrangements but the majority of the genes that are the target of t..

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